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1.
ABSTRACTPolicymakers and researchers are concerned with whether joint physical custody (JPC) produces better outcomes for children than sole custody. Although several review articles summarizing up to 61 empirical articles demonstrate very positive answers, many of the research designs used compromise the ability to claim that it is JPC per se—and not selection effects—that causes the effect. We discuss several research design issues, such as propensity score analysis, that can more powerfully probe the question of causality. Some studies have already been conducted employing these strategies and more are recommended and likely to soon be forthcoming. On the basis of this comprehensive review we conclude that JPC probably does cause benefits to children on average, and that social scientists can now provisionally recommend rebuttably presumptive JPC to policymakers. 相似文献
2.
Eliane R. Rodrigues Mario H. Tarumoto Guadalupe Tzintzun 《Journal of applied statistics》2019,46(3):395-415
In this work, we assume that the sequence recording whether or not an ozone exceedance of an environmental threshold has occurred in a given day is ruled by a non-homogeneous Markov chain of order one. In order to account for the possible presence of cycles in the empirical transition probabilities, a parametric form incorporating seasonal components is considered. Results show that even though some covariates (namely, relative humidity and temperature) are not included explicitly in the model, their influence is captured in the behavior of the transition probabilities. Parameters are estimated using the Bayesian point of view via Markov chain Monte Carlo algorithms. The model is applied to ozone data obtained from the monitoring network of Mexico City, Mexico. An analysis of how the methodology could be used as an aid in the decision-making is also given. 相似文献
3.
We propose a thresholding generalized method of moments (GMM) estimator for misspecified time series moment condition models. This estimator has the following oracle property: its asymptotic behavior is the same as of any efficient GMM estimator obtained under the a priori information that the true model were known. We propose data adaptive selection methods for thresholding parameter using multiple testing procedures. We determine the limiting null distributions of classical parameter tests and show the consistency of the corresponding block-bootstrap tests used in conjunction with thresholding GMM inference. We present the results of a simulation study for a misspecified instrumental variable regression model and for a vector autoregressive model with measurement error. We illustrate an application of the proposed methodology to data analysis of a real-world dataset. 相似文献
4.
Björn Bornkamp Kaspar Rufibach Jianchang Lin Yi Liu Devan V. Mehrotra Satrajit Roychoudhury Heinz Schmidli Yue Shentu Marcel Wolbers 《Pharmaceutical statistics》2021,20(4):737-751
A randomized trial allows estimation of the causal effect of an intervention compared to a control in the overall population and in subpopulations defined by baseline characteristics. Often, however, clinical questions also arise regarding the treatment effect in subpopulations of patients, which would experience clinical or disease related events post-randomization. Events that occur after treatment initiation and potentially affect the interpretation or the existence of the measurements are called intercurrent events in the ICH E9(R1) guideline. If the intercurrent event is a consequence of treatment, randomization alone is no longer sufficient to meaningfully estimate the treatment effect. Analyses comparing the subgroups of patients without the intercurrent events for intervention and control will not estimate a causal effect. This is well known, but post-hoc analyses of this kind are commonly performed in drug development. An alternative approach is the principal stratum strategy, which classifies subjects according to their potential occurrence of an intercurrent event on both study arms. We illustrate with examples that questions formulated through principal strata occur naturally in drug development and argue that approaching these questions with the ICH E9(R1) estimand framework has the potential to lead to more transparent assumptions as well as more adequate analyses and conclusions. In addition, we provide an overview of assumptions required for estimation of effects in principal strata. Most of these assumptions are unverifiable and should hence be based on solid scientific understanding. Sensitivity analyses are needed to assess robustness of conclusions. 相似文献
5.
6.
Dean Billheimer 《The American statistician》2019,73(1):291-295
ABSTRACTMost statistical analyses use hypothesis tests or estimation about parameters to form inferential conclusions. I think this is noble, but misguided. The point of view expressed here is that observables are fundamental, and that the goal of statistical modeling should be to predict future observations, given the current data and other relevant information. Further, the prediction of future observables provides multiple advantages to practicing scientists, and to science in general. These include an interpretable numerical summary of a quantity of direct interest to current and future researchers, a calibrated prediction of what’s likely to happen in future experiments, a prediction that can be either “corroborated” or “refuted” through experimentation, and avoidance of inference about parameters; quantities that exists only as convenient indices of hypothetical distributions. Finally, the predictive probability of a future observable can be used as a standard for communicating the reliability of the current work, regardless of whether confirmatory experiments are conducted. Adoption of this paradigm would improve our rigor for scientific accuracy and reproducibility by shifting our focus from “finding differences” among hypothetical parameters to predicting observable events based on our current scientific understanding. 相似文献
7.
Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
8.
Political support is a multidimensional construct encompassing evaluations of political leaders and institutions (specific support) as well as adherence to basic regime principles (diffuse support). Scholars have traditionally assumed that diffuse and specific support are driven by different forces and evolve largely independently. Prior empirical work, however, has struggled to untangle the two support dimensions and focused predominantly on cross-national differences, ignoring their dynamics. This paper develops an analytical and empirical approach to examine the levels and dynamic interplay of both support dimensions and estimate their determinants, applying it to South American democracies between 1996 and 2015. Contrary to received wisdom, we show that both dimensions are quite volatile and closely linked in this region. In particular, negative economic shocks not only undermine support for government actors, but also fuel democratic disenchantment. Nonetheless, while regime support is rather fickle in South America, it can be ultimately resistant to performance fluctuations. 相似文献
9.
Nan Bi Jelena Markovic Lucy Xia Jonathan Taylor 《Scandinavian Journal of Statistics》2020,47(1):212-249
We describe inferactive data analysis, so-named to denote an interactive approach to data analysis with an emphasis on inference after data analysis. Our approach is a compromise between Tukey's exploratory and confirmatory data analysis allowing also for Bayesian data analysis. We see this as a useful step in concrete providing tools (with statistical guarantees) for current data scientists. The basis of inference we use is (a conditional approach to) selective inference, in particular its randomized form. The relevant reference distributions are constructed from what we call a DAG-DAG—a Data Analysis Generative DAG, and a selective change of variables formula is crucial to any practical implementation of inferactive data analysis via sampling these distributions. We discuss a canonical example of an incomplete cross-validation test statistic to discriminate between black box models, and a real HIV dataset example to illustrate inference after making multiple queries on data. 相似文献
10.
Marcin Kozak Wojtek Krzanowski Izabela Cichocka James Hartley 《Journal of applied statistics》2015,42(9):2030-2037
Data input errors can potentially affect statistical inferences, but little research has been published to date on this topic. In the present paper, we report the effect of data input errors on the statistical inferences drawn about population parameters in an empirical study involving 280 students from two Polish universities, namely the Warsaw University of Life Sciences – SGGW and the University of Information Technology and Management in Rzeszow. We found that 28% of the students committed at least one data error. While some of these errors were small and did not have any real effect, a few of them had substantial effects on the statistical inferences drawn about the population parameters. 相似文献